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28/Aug/2019

Research shows that CBD can be used to decrease the frequency of seizures without the psychoactive properties of medical cannabis.

The World Health Organisation (WHO) announced that there medicinal and therapeutic benefits of cannabidiol (CBD) and one of the pathologies which can be treated is epilepsy.

Epilepsy is when two or more unprovoked and unexpected seizures arise. Seizures are brief episodes of involuntary movement that may involve the entire body (generalized) or a part of the body (partial).

Medically, refractory epilepsy remains an area of scientific interest as up to 35% of patients continue to suffer from seizures despite current therapies. Recent evidence has focused on the benefit of cannabidiol (CBD), a marijuana plant-based product with no psychoactive properties, can be used to decrease seizure frequency.

Medical Research with Oral CBD

In 2019, a group of researchers analysed several published articles of this pure oral CBD extract as an additional therapy for treating refractory epilepsy, Lennox-Gastaut and Dravet syndromes, convulsive seizures decrease by 50%. Additionally, in patients with treatment-resistant epilepsy of multiple aetiologies, similar benefits were observed.

Furthermore, a stopped/decreased dose of anti-seizure medication was observed when taking the CBD oil.

The therapeutic potential of CBD in epilepsy exists, however, further studies are still needed to better understand the full mechanism of action.

Source:

https://www.kalapa-clinic.com/en/new-stance-cbd-who/

 


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23/Aug/2019

The Obsessive-compulsive disorder(OCD) is a mental disorder marked by anxiety or distress, characterized by the presence of persistent thoughts (better known as obsessions). These recurrent thoughts are suppressed by new ones or actions, known as compulsions (acts performed in response to the obsession). The compulsions aim at preventing the anxiety or distress.

Around 60% of patients with Obsessive-Compulsive Disorder do not respond to first-line treatment. Options in these cases include an increase of dosages or switching to another drug. In this sense, new evidence reported patients with treatment-resistant OCD who could respond better to an increase dosage of medications combined with medical cannabis.

Clinical studies confirm effective results using cannabinoids in patients with OCD

In 2008, researchers published an article in the American Journal of Psychiatry. In this article, the researchers presented the experiences of two refractory OCD patients after synthetic THC administration.

To the female subject, doctors had prescribed for 8 months an antidepressant and psychological therapy to treat her OCD and major depression, but without success. Interestingly, the woman reported that when she smoked cannabis, her symptoms were relieved. It was then decided to supplement her current treatment with synthetic THC. Her OCD symptoms were reduced, and her severity disease score improved by 50%. Regarding the male subject, after the addition of the synthetic THC to the ongoing medication, his symptoms were reduced within 2 weeks, and his severity disease score improved by 35%.

In 2010, a clinical study was subsequently published in the Journal Behavioral Pharmacology, describing the observation of CBD effects on rodents. In this study, the researchers found that Cannabidiol (CBD) has been shown to have anxiolytic effects, both in animals and humans, could significantly reduce symptoms associated with stimulated compulsive animal behavior.

In general, these studies demonstrated a therapeutic potential of cannabinoids to reduce Refractory obsessive compulsive disorders. However, new studies are needed to definitively validate its utility or not.

Source:

https://www.kalapa-clinic.com/en/refractory-obsessive-compulsive-disorder/


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21/Aug/2019

Chronic pain (CP) is a long-lasting unpleasant sensorial and emotional experience without the acute warning signals of physiological nociception that persists past normal healing time and usually lasts or recurs for more than 3 months. It is a common and economically important health issue, affecting approximately 20% of people worldwide and accounting accordingly for 15-20% of medical consultations.

According to an exploratory analysis of anonymized 12-week open-label data provided by the German Pain e-Registry add-on treatment with the cannabis spray Sativex was effective and well-tolerated. Data were analyzed by scientists of the Institute of Neurological Sciences in Nuremberg, Germany, and other German institutions.
Among that 30.228 cases documented in the database in 2017, 800 (2.6%) received a treatment with Sativex containing THC and CBD in a ratio of about 1:1. Authors found a significant treatment effect.

Beneficial effects using CBD:THC oromucosal spray

Authors concluded that the Beneficial effects found for CP patients in this analysis clearly out weighted the potential risks of treatments and confirmed that THC:CBD oromucosal spray provides an effective add-on measure for patients suffering either from elsewhere refractory neuropathic pain conditions as well as those presenting with a pain phenotype suggestive for underlying neuropathic mechanisms.

Source:

Journal of Pain Research : Effectiveness and tolerability of THC:CBD oromucosal spray as add-on measure in patients with severe chronic pain


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