CBD was effective in reducing seizures in children with epilepsy
In a study with 16 patients with epilepsy with an average age of 9 years old, a high-purity CBD preparation reduced the frequency of seizures. The study was conducted at Dana-Dwek Children’s Hospital in Tel Aviv, Israel. This prospective Phase II study was open to pediatric patients with treatment-resistant epilepsy at stable doses of antiepileptic drugs who suffered at least 4 seizures within 4 weeks. After a four-week observation period, patients began a two-week dose titration phase (up to 25mg/kg or 450mg, the lower of the two) followed by a ten-week maintenance treatment.
Of the 16 participants, 11 completed the entire treatment program. The average maintenance dose was 14 mg CBD per kilogram body weight. At the end of the treatment period, there was an average reduction in monthly seizure frequency of 73% compared to baseline. Two patients were completely free of seizures. 73% of the nurses stated that the condition was improved or greatly improved. The most frequently reported treatment-related adverse events were sleep disorders/insomnia (25% of patients), followed by drowsiness, increased seizure frequency, and restlessness (3 patients each (19%)). No side effect was serious or severe and all disappeared by themselves.
Mitelpunkt A, Kramer U, Hausman Kedem M, Zilbershot Fink E, Orbach R, Chernuha V, Fattal-Valevski A, Deutsch L, Heffetz D, Sacks H. The safety, tolerability, and effectiveness vom PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study. Epilepsy Behav. 2019;98(Pt A):233-237.