Antiseptic mouthwashes are often used for prophylaxis in the oral cavity. Depending on the ingredients, such as chlorhexidine, cetylpyridinium chloride, floride or alcohol, these are said to be effective against gum inflammation, tooth erosion, plaque or caries.
Belgian researchers have now carried out an interesting study in which they added the cannabinoids cannabidiol (CBD) and cannabigerol (CBG) to mouthwash products and had volunteers test them.
The antiseptic effect of cannabinoids
In addition to the well-known cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), the cannabis plant contains more than 100 other cannabinoids, including cannabigerol (CBG). Various studies have already shown that CBD can have an anti-inflammatory and antiseptic effect.
The cannabinoid CBG is less well researched, but it is increasingly becoming the focus of scientific attention. Thus CBG is also attributed anti-inflammatory and antibacterial properties. It is particularly interesting to note that CBG, in combination with other cannabinoids like CBD, could have similar effects to antibiotics. This is shown in a study from 2008, although the exact mechanisms are still unknown.
Results of the study
The mouthwash products contained less than one percent of the cannabinoids CBD and CBG. To compare efficacy, the researchers included two conventional mouthwash products (product A and product B) in the study. Chlorhexidine digluconate 0.2 percent was used as a positive control. The products were tested on plaque samples from 72 adults.
In conclusion, the researchers stated that the CBD and CBG added mouthwash products showed on average a similar bactericidal efficacy as chlorhexidine 0.2 percent in the samples tested.
In contrast, no significant antimicrobial effect was observed for product A, except for a low level of inhibition in nine samples. In the case of product B, no inhibition could be detected in any sample either.
According to the researchers, these results show the potential of CBD and CBG, so that mouthwash and oral care products containing cannabinoids could be the next generation without alcohol and without fluoride.