It was always suspected that CBD can reverse the psychiatric side effects of THC, however, researchers at Western University has proven this by showing the molecular mechanisms at work in the hippocampus.
It wasn’t known why high levels of THC and low levels of CBD caused psychiatric effects such as paranoia, anxiety and even addictive behaviours. At Western’s Schulich School of Medicine & Dentistry, Professor Steven Laviolette and his team were able to identify which cannabidiol may actually block the psychoactive THC by using rats to investigate a molecule in the brain’s hippocampus which triggers the effects of THC, the extra cellular-signal regulated kinase (ERK).
CBD can block THC psychoactive effects
In their study, rats which were given more THC showed higher levels of activated ERK causing higher anxiety like behaviours. When given only CBD, it had no effect in the ERK pathway. However, with CBD and THC combined it showed normal levels of active ERK, leading to lower anxiety levels. According to this study, it provides strong evidence that CBD can block the THC’s psychoactive effects, by avoiding overstimulation in the ERK.
This finding shows great importance for prescribing medicinal cannabis by assuring effective and safe THC formulations