ADHD

ADHD is a neurological disorder that can affect people at different stages of life. The disorder manifests itself primarily in hyperactivity (excessive urge to move), inattention (impaired ability to concentrate) and impulsivity (rash behavior) and affects an estimated 5% of all children and 2.5% of all adults worldwide (1,3). In addition to behavioral therapy, other approaches are often based on stimulants or other medications (2). These methods are considered relatively safe and effective, but are often associated with decreased appetite, insomnia, emotional dysregulation, irritability and an increased risk of adverse cardiovascular events (1). 
There is evidence that cannabinoids may play a promising role in the symptom management of ADHD due to their neuroprotective and anti-inflammatory properties.

Endocannabinoidsystem (ECS)

The endocannabinoid system (ECS) can be described as a signaling network of the body that consists of cannabinoid receptors (type 1 and type 2), among others. CB1 receptors are widely distributed throughout the central nervous system, with high concentrations detected in regions associated with cognitive function and processing. Therefore, activation of CB1 receptors directly or by increasing AEA, an endogenous ligand of CB1 receptors whose activation leads to modulation of neurotransmitter release, is thought to be a potential target for the treatment of ADHD (1).   

ADHD study

In a study conducted by the British Medicinal Cannabis Registry in 2023, a total of 68 participants diagnosed with ADHD were treated with medicinal cannabis over a period of 12 months. Inhaled preparations of dried flowers and sublingual oil preparations were prescribed individually and in combination. The results of the study show that, among other things, the severity of anxiety and sleep quality as well as the general health-related quality of life could be improved.

These findings may open up new avenues for personalized treatment approaches that are better tailored to the individual needs of people with ADHD.  

Further studies are needed to understand the long-term effects and optimal mode of action. Nevertheless, the discovery of new treatment options has the potential to support conventional therapeutic approaches and improve the lives of those affected through symptom relief.   

 

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